The EAWAG-BBD Tyrosine Pathway

• trans,cis-5-Carboxymethyl-2-hydroxymuconate -----> cis-5-Carboxymethyl-2-oxohex-3-ene-1,6-dioate (reacID# r0366)
• trans,cis-5-Carboxymethyl-2-hydroxymuconate semialdehyde -----> trans,cis-5-Carboxymethyl-2-hydroxymuconate (reacID# r0365)
• cis-5-Carboxymethyl-2-oxohex-3-ene-1,6-dioate -----> cis-2-Oxohept-3-ene-1,7-dioate (reacID# r0367)
• 4-Chlorophenylacetate -----> 3,4-Dihydroxyphenylacetate (reacID# r0308)
• 2,4-Dihydroxy-hept-trans-2-ene-1,7-dioate -----> Succinic semialdehyde + Pyruvate (reacID# r0370)
• 3,4-Dihydroxyphenylacetate -----> trans,cis-5-Carboxymethyl-2-hydroxymuconate semialdehyde (reacID# r0364)
• Fumarylacetoacetate -----> Fumarate + Acetoacetate (reacID# r0107)
• Homogentisate -----> 4-Maleylacetoacetate (reacID# r0105)
• 4-Hydroxyphenylacetate -----> 3,4-Dihydroxyphenylacetate (reacID# r0301)
• 4-Hydroxyphenylacetate -----> Homogentisate (reacID# r0300)
• 4-Hydroxyphenylpyruvate -----> Homogentisate (reacID# r0298)
• 4-Hydroxyphenylpyruvate -----> 4-Hydroxyphenylacetate (reacID# r0299)
• 4-Maleylacetoacetate -----> Fumarylacetoacetate (reacID# r0106)
• cis-2-Oxohept-3-ene-1,7-dioate -----> 2,4-Dihydroxy-hept-trans-2-ene-1,7-dioate (reacID# r0369)
• Succinic semialdehyde -----> Succinate (reacID# r0371)
• L-Tyrosine -----> 4-Hydroxyphenylpyruvate (reacID# r0297)

• Acetoacetate [541-50-4] (compID# c0069)
• trans,cis-5-Carboxymethyl-2-hydroxymuconate (compID# c0306)
• trans,cis-5-Carboxymethyl-2-hydroxymuconate semialdehyde [2461-62-3] (compID# c0305)
• cis-5-Carboxymethyl-2-oxohex-3-ene-1,6-dioate (compID# c0307)
• 4-Chlorophenylacetate [1878-66-6] (compID# c0385)
• 2,4-Dihydroxy-hept-trans-2-ene-1,7-dioate (compID# c0310)
• 3,4-Dihydroxyphenylacetate [102-32-9] (compID# c0272)
• Fumarate [110-17-8] (compID# c0111)
• Fumarylacetoacetate [28613-33-4] (compID# c0110)
• Homogentisate [451-13-8] (compID# c0108)
• 4-Hydroxyphenylacetate [156-38-7] (compID# c0271)
• 4-Hydroxyphenylpyruvate [156-39-8] (compID# c0235)
• 4-Maleylacetoacetate [5698-52-2] (compID# c0109)
• cis-2-Oxohept-3-ene-1,7-dioate (compID# c0309)
• Pyruvate [127-17-3] (compID# c0159)
• Succinate [110-15-6] (compID# c0312)
• Succinic semialdehyde [692-29-5] (compID# c0311)
• L-Tyrosine [60-18-4] (compID# c0234)

• EC 1.2.1.16 succinic semialdehyde dehydrogenase (enzymeID# e0020)
• EC 1.2.1.60 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase (enzymeID# e0280)
• EC 1.2.3.13 4-hydroxyphenylpyruvate oxidase (enzymeID# e0244)
• EC 1.13.11.5 homogentisate 1,2-dioxygenase (enzymeID# e0081)
• EC 1.13.11.15 3,4-dihydroxyphenylacetate 2,3-dioxygenase (enzymeID# e0125)
• EC 1.13.11.27 4-hydroxyphenylpyruvate dioxygenase (enzymeID# e0126)
• EC 1.14.12.9 4-chlorophenylacetate 3,4-dioxygenase (enzymeID# e0290)
• EC 1.14.13.18 4-hydroxyphenylacetate 1-hydroxylase (enzymeID# e0151)
• EC 1.14.14.9 4-hydroxyphenylacetate 3-hydroxylase (enzymeID# e0150)
• EC 2.6.1.5 aromatic aminotransferase (enzymeID# e0142)
• EC 3.7.1.2 fumarylacetoacetase (enzymeID# e0083)
• EC 4.1.1.68 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase (enzymeID# e0137)
• EC 4.1.3.- 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase (enzymeID# e0282)
• EC 4.2.1.- 2-oxo-hept-3-ene-1,7-dioate hydratase (enzymeID# e0281)
• EC 5.2.1.2 maleylacetoacetate isomerase (enzymeID# e0082)
• EC 5.3.3.10 5-carboxymethyl-2-hydroxymuconate isomerase (enzymeID# e0135)

Page Author(s): Michelle Wagner, Colin L. Sweeney and Zhifu Sun
December 15, 1997 5:06:20 PM CST Contact Us

This is the EAWAG-BBD compounds and reactions page for the Tyrosine Pathway.
It was generated on February 18, 2026 4:18:54 PM CST.

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