From Homogentisate to 4-Maleylacetoacetate

Graphic of the reaction.

Medline reference
Fernandez-Canon JM, Penalva MA. J Biol Chem (1995) 270(36): 21199-205.

Search Medline titles for homogentisate AND dioxygenase.
23 citations on March 09, 2012. 
            Homogentisate            
                  |
                  |  O2
    homogentisate | /
  1,2-dioxygenase |/
        1.13.11.5 | Search GenBank, 63 hits on Apr. 03, 2012
            Kyoto |\
           ExPASy | \
                  |  H+
                  v
        4-Maleylacetoacetate
Display a pathway starting from this reaction.

EAWAG-BBD Biotransformation rules in accord with this reaction:
1,4-Dihydroxy-2-substituted -----> intrasubstituent ring cleavage (bt0174)
[Phenylacetate] [Styrene] [Tyrosine] [BBD Main Menu]

Page Author(s): Colin L. Sweeney
August 14, 2005 Contact Us

This is the EAWAG-BBD reaction, reacID# r0105.
It was generated on November 7, 2025 at 3:30:06 PM CST. 

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