2-Aminobenzoate Pathway Map

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This pathway was contributed by Jingfeng Feng, University of Minnesota.

2-Aminobenzoate is an intermediate derived from tryptophan and other indole ring-containing compounds. The catabolism of 2-aminobenzoic acid has been well-studied. Here we only addressed the aerobic biodegradation pathway, the anaerobic pathway is documented elsewhere in the UMBBD.

Pseudomonas sp. KB740 transforms 2-aminobenzoate to 1,4-cyclohexadione via 2-amino-5-oxo-cyclohex-1-enecarboxy-CoA (Altenschmidt et al., 1991). Other pseudomonads transform it directly to catechol (Taniuchi et al., 1964). The fungus Aspergillus niger takes two steps to get to the same end (Kamath & Vaidyanathan, 1990).

The following is a text-format 2-aminobenzoate pathway map. Organisms which can initiate the pathway are given, but other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in graphic ( 11k ) format.

                                   from the
                                o-Nitrobenzoate, 
                                Quinaldine and
                              Carbazole Pathways 
                                    |  |
            2-Aminobenzoate         |  |     2-Aminobenzoate      2-Aminobenzoate 
         Pseudomonas sp. KB740 <----+  +-->  Pseudomonas sp.     Aspergillus niger
                   |                     Pseudomonas aureofaciens      |
                   |                                |                  |
  anthranilate-CoA |                                |                  | anthranilate
            ligase |                                |                  | 3-monooxygenase
                   |                                |                  |
                   v                   anthranilate |                  v                           from the
          2-Aminobenzoyl-CoA        1,2-dioxygenase |        2,3-Dihydroxybenzoate <---------- Phthalate Family
                   |                                |                  |                            Pathway
                   |                                |                  | 2,3-dihydroxybenzoate
  anthraniloyl-CoA |                                |                  | decarboxylase
     monooxygenase |                                |                  |
                   |                                +-------+  +-------+
                   |                                        |  |
                   v                                        v  v     
 2-Amino-5-oxo-cyclohex-1-enecarboxy-CoA                  Catechol
                   |                                         |
                 A |                                         | 
                   v                                         |
                   |                                         v
                   v                                       to the
         1,4-Cyclohexanedione                       Nitrobenzene Pathway

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Page Author(s): Jingfeng Feng and Michael Turnbull

July 11, 2017 Contact Us

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