2-Aminobenzoate Pathway (Anaerobic)

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This pathway was contributed by Vidhya Iyer and completed by Jian Ma, University of Minnesota.

2-Aminobenzoate is an intermediate derived from tryptophan and other indole ring-containing compounds. The catabolism of 2-aminobenzoate has largely been studied with aerobic bacteria. Its aerobic degradation is documented elsewhere in the EAWAG-BBD. More recently, anaerobic catabolism of 2-Aminobenzoate has been studied and proceeds with initial esterification of the carboxyl group to coenzyme A (Altenschmidt et al., 1991). The subsequent proposed reduction of 2-aminobenzoyl-CoA to benzoyl-CoA is reminiscent of reductive deamination reported for the catabolism of nitroaromatic compounds, such as trinitrotoluene (TNT), following reduction of the nitro groups to form an aniline derivative (Lochmeyer et al., 1992).

The following is a text-format 2-aminobenzoate pathway map. Organisms which can initiate the pathway are given, but other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in Graphic (7k) format.

 
              2-Aminobenzoate <------ from the Carbazole Pathway, o-Nitrobenzoate Pathway              
              Pseudomonas sp.              and Quinaline Pathway   
               KB 740, K 172
                     |
                     |
                     | anthranilate-CoA
                     | ligase
                     | 
                     |
                     v
             2-Aminobenzoyl-CoA
                     |
                     |
                     | 2-aminobenzoyl-CoA
                     | reductase
                     | 
                     |
                     v
                Benzoyl-CoA
                     |
                     |
                     |
                     |
                     |
                     |
                     v
                   to the
              Benzoate Pathway
                (Anaerobic)


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Page Author(s): Vidhya Iyer and Jian Ma

June 30, 2014 Contact Us

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