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December 14, 2001
Pathways for the biodegradation of 1-methylnaphthalene (US) or (UK) and 2-methylnaphthalene (US) or (UK) have been added. Each of these pathways includes a reaction catalyzed by the versatile enzyme naphthalene 1,2-dioxygenase. These reactions have been added to the list of Reactions of Naphthalene 1,2-Dioxygenase (US) or (UK), bringing to 75 the number of such reactions. The nitrophenol pathway (US) or (UK) has been updated. A link has been added to the International Union of Biochemistry and Molecular Biology (IUBMB) Enzyme Nomenclature database entry to all enzyme pages for which IUBMB has assigned a complete four-digit EC code; for example, naphthalene 1-2-dioxygenase, EC 1.14.12.12. The link is labelled "IUBMB". The IUBMB page for these enzymes links back to the UM-BBD. As requested by a UM-BBD user, the list of all UM-BBD compounds and each list of compounds in a pathway (for example, those in the 1-methylnaphthalene pathway), now includes CAS Registry Numbers when they are known to us. If you find the CAS number for a UM-BBD compound that does not have one, please let us know. On the Useful Internet Resources page, the links to NLM Chemical Information and Environmental Programs at the Lawrence Livermore National Laboratory have been updated and the link to Aitken, et al. Spring 1997 ESE NOTES, University of North Carolina has been removed.

November 8, 2001
Pathways for the biodegradation of 1-naphthoic acid (US) or (UK), and immobilization of uranium (US) or (UK), have been added. On the Useful Internet Resources page, a link has been added for the Microbial Genomics Gateway from the US Department of Energy and the link to the EPA Citizen's Guide to Bioremediation PDF file has been updated. Speed of searches and generating lists of information has been increased. The US Department of Energy is now supporting the growth of the UM-BBD through its Microbial Genome Program. A link to this program has been added to the UM-BBD Acknowledgements page.

October 12, 2001
A pathway for the organometallic compound triphenyltin (US) or (UK), has been added. We will be adding more examples of microbial metabolism of metals, metalloids and metal chelators. A list of such pathways is now available. It is linked to on the search and browse page. Links to BRENDA on enzyme pages have been updated. A list of all enzyme pages is available. Students in our 2001 Biocatalysis and Biodegradation class, offered completely over the Internet, have examined websites on the UM-BBD Useful Internet Resources page and selected the most interesting ones. The Useful Internet Resources page now links to the list of these choices and the reason each site was selected. On the Useful Internet Resources page, the link for the Southwestern Biotechnology and Informatics Center has been updated. A new review of the UM-BBD has been added to the Publications page: Uwe Bornscheuer, Angew. Chem. (2001) 113: 3817; Angew. Chem. Int. Ed. Engl. (2001) 40: 3703.

August 28, 2001
A pathway for dimethylphosphinic acid (US) or (UK), has been added. Phosphinic acid is the 50th UM-BBD functional group; a list of all functional groups is available. Links to ChemFinder on compound pages have been updated. A list of all compound pages is available. BioC/MicE 5309, Biocatalysis and Biodegradation, a University of Minnesota class offered completely over the Internet, is full and registration has closed for this year. The class will run from September 4 - December 14, 2001. On the Useful Internet Resources page, the link for PathDB: Metabolic Pathways Database at NCGR, has been updated, and the link for Elsevier Science BIOtech has been removed.

July 13, 2001
A new pathway for cyclohexylsulfamide (cyclamate) (US) or (UK), has been added and the pathway for vanillin (US) or (UK), has been updated. On the Useful Internet Resources page, a link has been added for ChemSpy: The Internet Navigator for the Chemical Industry.

May 22, 2001
A new pathway for vanillin (US) or (UK), has been added and the pathways for 2,4-dichlorobenzoate (US) or (UK), and 4-nitrophenol (US) or (UK), have been updated. A UM-BBD user recommended these changes. The results of the Sixth Annual User Survey are now available. New publication: Ellis, Lynda B.M. and Attwood, Teresa K. (2001) "Molecular biology databases: today and tomorrow" Drug Discovery Today 6(10): 509-513. On the Useful Internet Resources page, a link has been updated for Designated Hazardous Substances from the Australian National Occupational Health and Safety Commission. Links have been removed for OSHA Chemical Information; and Biocatalysis, Institute for Organic Chemistry, Technical University Granz, Austria.

April 25, 2001
The pathways for gamma-1,2,3,4,5,6-hexachlorocyclohexane (Lindane) (US) or (UK), m-cresol (US) or (UK), and styrene (US) or (UK) have been updated. Members of our email users list recommended these updates. On the Useful Internet Resources page, links have been added for National Academy Press (NAP), a search of the text of NAP books for "biodegradation" and the NAP book: Natural Attenuation for Groundwater Remediation (2000). A link has been updated for Ecocyc.

March 15, 2001
A pathway for alpha-Pinene (US) or (UK) has been added. This pathway was started by a student in our 2000 Biocatalysis and Biodegradation class. New publication: Lawrence P. Wackett and C. Douglas Hershberger (2001) Biocatalysis and Biodegradation: Microbial Transformation of Organic Compounds. ASM Press, Wash. DC. xxiii+228p. ISBN 1-55581-179-5. All reaction pages were reviewed. New Medline searches were added and older ones were updated to be more specific. Almost all reaction pages contain Medline searches. A list of all reactions, alphabetized by reactant, is available. On the Useful Internet Resources page, links have been added for the Biopathways Consortium, the International Society for the Study of Xenobiotics, the U.S. EPA Citizen's Guide to Bioremediation, EMP: Enzyme and Metabolic Pathway Database at Argonne National Laboratory, and the Environmental Fate Database from Syracuse Research Corporation; a link has been updated for the Alternate Crops and Systems Lab (ACSL) Pesticide Properties Database; and links have been removed for U.S. EPA Bioremediation Resource Guide - September 1993, and ChemExper.

February 1, 2001
A pathway for Limonene (US) or (UK) has been added. This pathway includes contributions from a student in our 2000 Biocatalysis and Biodegradation class. The IUBMB Enzyme Nomenclature website now links back to UM-BBD enzyme entries. For example, in the section for the enzyme subgroup 1.14.12, most members of that subgroup have links to the UM-BBD. All 643 UM-BBD compound pages were reviewed and an additional 78 links to molecular model and other information were added. A list of all compounds in alphabetical order is available. Recent review: Wedin, R. (2000) "Review: The University of Minnesota Biocatalysis/Biodegradation Database" Chemistry, Fall 2000, American Chemical Society, p. 6. This and other reviews are available on the UM-BBD publication page. Recent publication: Ellis, L.B.M., Hershberger, C.D., Bryan, E.M. and Wackett, L.P. (2001) "The University of Minnesota Biocatalysis/ Biodegradation Database: Emphasizing Enzymes" Nucleic Acids Research 29: 340-343. The full text of this paper in .pdf format is available on the UM-BBD main menu and the publications page. Use this paper or its successors to cite the database. The policy of the UM-BBD has always been to respect the privacy of all its web site visitors to the extent permitted by law. This policy is now explicitly listed on a Privacy Policy page. On the Useful Internet Resources page, links have been added for Yeast Genome Pathways from MIPS, Germany, and Bacterial Biodegradation Of High Molecular Weight Polycyclic Aromatic Hydrocarbons, Aitken, et al. Spring 1997, ESE NOTES, University of North Carolina, and links have been updated for the Bioremediation Discussion Group, the Search of the National Toxicology Program website, and OSHA Chemical Sampling Information. The WIT resource from Integrated Genomics was renamed ERGO. The What's New page restarts; 2000 activities have been archived.

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