Sodium cyclohexylsulfamate (CHS-Na), also known as sodium cyclamate, was a widely used sweetening agent. It was banned for general use in 1969 because of the suspicion of carcinogenicity and metabolic conversion to cyclohexylamine (CHA), a toxic substance. A Pseudomonas species can desulfate CHS-Na to CHA using the enzyme cyclamate sulfamatase (Nimura et al., 1974). Also, this bacterium can deamine cyclohexylamine (CHA) to cyclohexanone (CHnone) using the enzyme cyclohexylamine oxidase (CHA-oxidase) (Tokieda et al., 1977).
The following is a text-format Cyclohexylsulfamate pathway map. An organism which can initiate the pathway is given, but other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in graphic (10k) format.
Cyclohexylsulfamate Pseudomonas sp. | | | cyclamate | sulfamatase | v from the Cyclohexylamine <--- N-Cyclohexylisocyanide | Pathway | | cyclohexylamine | oxidase | v Cyclohexanone | | | V to the Cyclohexane Pathway
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