2,4-Dichlorobenzoate is a key intermediate in the aerobic biodegradation of some of the 209 polychlorinated biphenyl (PCB) congeners. These are important environmental pollutants relatively resistance to biodegradation. This pathway includes 4-chlorobenzoate, an intermediate for preparation of dyes, fungicides, pharmaceuticals and other organic chemicals; and a preservative for adhesives and paints. It is based on Romanov et al., 1996; and Scholten et al., 1991.
The following is a text-format 2,4-Dichlorobenzoate pathway map. Organisms which can initiate the pathway are given, but other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in graphic (12k) format.
2,4-Dichlorobenzoate
Achromobacter xylosoxidans from the
subsp. denitrificans NTB-1 4-Chlorobiphenyl
Clavibacter michiganense Pathway
subsp. sepedonicum KZ-4 |
| |
| 2,4-dichloro- |
| benzoate |
| CoA ligase v from the
| 4-Chlorobenzoate <------ DDT Pathway
| Pseudomonas sp. CBS3
v Alcaligenes sp. AL3007
2,4-Dichlorobenzoyl-CoA Arthrobacter sp. 4-CB1, SU
| |
| | 4-chloro-
| 2,4-dichloro- | benzoate
| benzoyl-CoA | CoA ligase
| reductase |
| |
| +--------------------------+
v v
4-Chlorobenzoyl-CoA
|
|
| 4-chlorobenzoyl-CoA
| dehalogenase
|
|
v from the
4-Hydroxybenzoyl-CoA <------ 4-Fluorobenzoate
| Pathway
| 4-hydroxy-
| benzoyl-CoA
| thio-
| esterase
|
v
4-Hydroxybenzoate
|
|
|
|
v
to the
Vanillin Pathway
Page Author(s): Yoav Dori, Dong Jun Oh, and Stephen Stephens
Contact Us© 2024, EAWAG. All rights reserved. http://eawag-bbd.ethz.ch/dcb/dcb_map.html