2,4-Dichlorobenzoate is a key intermediate in the aerobic biodegradation of some of the 209 polychlorinated biphenyl (PCB) congeners. These are important environmental pollutants relatively resistance to biodegradation. This pathway includes 4-chlorobenzoate, an intermediate for preparation of dyes, fungicides, pharmaceuticals and other organic chemicals; and a preservative for adhesives and paints. It is based on Romanov et al., 1996; and Scholten et al., 1991.
The following is a text-format 2,4-Dichlorobenzoate pathway map. Organisms which can initiate the pathway are given, but other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in graphic (12k) format.
2,4-Dichlorobenzoate Achromobacter xylosoxidans from the subsp. denitrificans NTB-1 4-Chlorobiphenyl Clavibacter michiganense Pathway subsp. sepedonicum KZ-4 | | | | 2,4-dichloro- | | benzoate | | CoA ligase v from the | 4-Chlorobenzoate <------ DDT Pathway | Pseudomonas sp. CBS3 v Alcaligenes sp. AL3007 2,4-Dichlorobenzoyl-CoA Arthrobacter sp. 4-CB1, SU | | | | 4-chloro- | 2,4-dichloro- | benzoate | benzoyl-CoA | CoA ligase | reductase | | | | +--------------------------+ v v 4-Chlorobenzoyl-CoA | | | 4-chlorobenzoyl-CoA | dehalogenase | | v from the 4-Hydroxybenzoyl-CoA <------ 4-Fluorobenzoate | Pathway | 4-hydroxy- | benzoyl-CoA | thio- | esterase | v 4-Hydroxybenzoate | | | | v to the Vanillin Pathway
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