2,4-Dichlorobenzoate Pathway Map

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This pathway was started by Yoav Dori and completed by Dong Jun Oh and Stephen Stephens, University of Minnesota.

2,4-Dichlorobenzoate is a key intermediate in the aerobic biodegradation of some of the 209 polychlorinated biphenyl (PCB) congeners. These are important environmental pollutants relatively resistance to biodegradation. This pathway includes 4-chlorobenzoate, an intermediate for preparation of dyes, fungicides, pharmaceuticals and other organic chemicals; and a preservative for adhesives and paints. It is based on Romanov et al., 1996; and Scholten et al., 1991.

The following is a text-format 2,4-Dichlorobenzoate pathway map. Organisms which can initiate the pathway are given, but other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in graphic (12k) format.

             Achromobacter xylosoxidans              from the
              subsp. denitrificans NTB-1          4-Chlorobiphenyl
               Clavibacter michiganense                Pathway
                subsp. sepedonicum KZ-4                  |
                           |                             |
                           | 2,4-dichloro-               |
                           | benzoate                    |
                           | CoA ligase                  v                   from the
                           |                     4-Chlorobenzoate  <------ DDT Pathway
                           |                   Pseudomonas sp. CBS3
                           v                  Alcaligenes sp. AL3007
                2,4-Dichlorobenzoyl-CoA     Arthrobacter sp. 4-CB1, SU
                           |                             |
                           |                             | 4-chloro-
                           | 2,4-dichloro-               | benzoate
                           | benzoyl-CoA                 | CoA ligase
                           | reductase                   |
                           |                             |
                           |  +--------------------------+
                           v  v
                           | 4-chlorobenzoyl-CoA
                           | dehalogenase
                           v                       from the
                  4-Hydroxybenzoyl-CoA <------ 4-Fluorobenzoate 
                           |                       Pathway
                           | 4-hydroxy- 
                           | benzoyl-CoA                          
                           | thio-
                           | esterase
                        to the
                    Vanillin Pathway   

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Page Author(s): Yoav Dori, Dong Jun Oh, and Stephen Stephens

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