Benzene compounds with dihydroxylated rings, e.g. catechol (1,2-benzenediol) and hydroquinone (1,4-benzenediol), are important intermediates in bacterial catabolism of aromatic compounds. The bacterial catabolism of orcinol (5-methyl-1,3-benzenediol) can be used as a model for the metabolism of other members of the resorcinol (1,3-benzenediol) compound family. This family includes many commercially-important compounds; for example, 4-hexylresorcinol is used medicinally as a topical antiseptic.
This pathway is based on Chapman and Ribbons (1976).
The following is a text-format orcinol pathway map. An organism which can initiate the pathway is given, but other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in graphic (5k) format.
Orcinol Pseudomonas putida | | | orcinol hydroxylase | | v 2,3,5-Trihydroxytoluene | | | 2,3,5-trihydroxytoluene 1,2-dioxygenase | | v 2,4,6-Trioxoheptanoate | | | 2,4,6-trioxoheptanoate hydrolase | | v Acetylpyruvate + Acetate | | | acetylpyruvate hydrolase | | v Pyruvate + Acetate | | | | | | | | | | | | v v Intermediary Intermediary Metabolism Metabolism (KEGG) (KEGG)
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