4-Carboxy-4'-sulfoazobenzene Pathway Map

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This pathway was contributed by Ben Vickers, University of Minnesota.

The following pathway describes the metabolic breakdown of 4-Carboxy-4'-Sulfoazobenzene utilizing a bacterial strain (S5) adapted from Hydrogenophaga palleronii S1. Though it is generally thought that azo dyes are degraded only anaerobically, there have been recent reports to suggest otherwise. This is the first aerobic bacterial stain reported to utilize an azo dye as its sole source of carbon and energy (Blumel et al., 1998).

In the first step of the pathway, the S5 strain cleaves 4-Carboxy-4'-Sulfoazobenze aerobically to 4-aminobenzoate and 4-aminobenzenesulfonate. These compounds are then degraded by previously determined metabolic pathways.

The following is a text-format asulam degradation pathway map. Organisms which can initiate the pathway are given, but other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in a graphic (7k) format.

                                        4-Carboxy-4'-sulfoazobenzene
                                          Hydrogenophaga palleroni
                                                 Strain S5
                                                     |         
                                                     |          
                                                     | 4-Carboxy-4'-sulfoazobenzene
                                                     | reductase           
                                                     |             
        Agaricus bisporus                            V              
                +---------------- 4-Aminobenzoate    +     4-Aminobenzenesulfonate
                |                         |                           |
                |                         |                           |
4-aminobenzoate |         4-aminobenzoate |                           |
    hydroxylase |         3,4-dioxygenase |                           |
                |           (deaminating) |                           |
                |                         |                           |
                v                         v                           v
         p-Aminophenol          3,4-Dihydroxybenzoate               to the
                |                         |                     Asulam Pathway
                |                         |
                |                         |
                |                         |
                |                         |
                v                         v
              to the                    to the
             Parathion            2,4-Diclorobenzoate
              Pathway                   Pathway

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Page Author(s): Ben Vickers

September 13, 2011 Contact Us

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