Acetylene (an/aerobic) Pathway Map

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This pathway was contributed by Jennifer Seffernick and Jingfeng Feng, University of Minnesota and updated with information provided by Bettina Rosner, Dow AgroSciences.

Acetylene is a highly flammable gas and forms explosive mixtures with air over an unusually wide range of concentrations (2 to 80%). Acetylene can polymerize exothermically, leading to deflagration. Acetylene is relatively nontoxic and has been used as an anesthetic. Inhalation of acetylene can be hazardous because of its action as a simple asphyxiant. Acetylene is also well known for its inhibitory properties and its interactions with microbial processes such as nitrogen fixation, nitrous oxide reduction, ammonium oxidation, methanogenesis and alkane oxidation.

Rhodococcus spp. can aerobically metabolize acetylene through reactions catalyzed by the enzyme acetylene hydratase (Kanner & Bartha, 1982), and Klebsiella penumonia can do the same using nitrogenase (Lowe et al., 1990). The strict anaerobe Pelobacter acetylenicus can also carry out the acetylene hydratase reaction (Rosner & Schink, 1982).

The following is a text-format Acetylene pathway map. Organisms which can initiate the pathway are given, but the other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in graphic (8k) format.

       Acetylene                          Acetylene
    Rhodococcus sp.                 Klebsiella pneumonia
   Rhodococcus opacus                    NCIB 12204       
Rhodococcus rhodochrous                       |
Pelobacter acetylenicus                       |
           |                                  |
           | acetylene                        | nitrogenase
           | hydratase                        | 
           |                                  |
           |                                  |
           v                                  v                           from the 
      Acetaldehyde                         Ethylene  <---------- Tetrachloroethene Pathway
           |                                  |
           |                                  | alkene
           |                                  | monooxygenase
           v                                  |
     Intermediary                             v
      Metabolism                        Ethylene Oxide      
        (KEGG)                                |
                                              |
                                              |
                               +--------------+--------------+
                               |                             |
                               | epoxide                     | epoxide
                               | hydrolase                   | dehydrogenase
                               |                             |
                               v                             v
                        Ethylene Glycol                  Acetyl-CoA
                               |                             |
                               |                             |
                               |                             |
                               v                             v
                         Intermediary                   Intermediary 
                          Metabolism                     Metabolism
                            (KEGG)                         (KEGG)

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Page Author(s): Jingfeng Feng

April 17, 2013 Contact Us

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