From 1,2,3,4-Tetrachlorobenzene to cis-Chlorobenzene dihydrodiol

Graphic of the reaction.

Medline reference
Werlen C, Kohler HP, van der Meer JR. J Biol Chem (1996) 271(8): 4009-16.

Search Medline for chlorobenzene dioxygenase AND bacteria.
16 citations on March 09, 2012. 
    1,2,3,4-Tetrachlorobenzene    
                 |
                 |  O2 + NAD(P)H + H+
   chlorobenzene | /
     dioxygenase |/
       1.14.12.- | Search GenBank, 10 hits on Apr. 03, 2012
                 |\
          ExPASy | \
                 |  NAD(P)+
                 v
  cis-Chlorobenzene dihydrodiol
Display a pathway starting from this reaction.

EAWAG-BBD Biotransformation rules in accord with this reaction:
vic-unsubstituted Aromatic -----> vic-Dihydrodihydroxyaromatic (bt0367)
[Tetrachlorobenzene] [BBD Main Menu]

Page Author(s): Yan Zhang
August 14, 2005 Contact Us

This is the EAWAG-BBD reaction, reacID# r0800.
It was generated on July 14, 2026 at 5:08:08 PM CDT. 

© 2026, EAWAG.