Tetrachlorobenzene Pathway Map

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This pathway was contributed by Yan Zhang (BioC/MicE 5309) and Prasad Kotharu, University of Minnesota.

1,2,3,4-Tetrachlorobenzene is a highly recalcitrant pollutant used as a component of dielectric fluids and in organic synthesis. Pseudomonas chlororaphis RW71 mineralizes 1,2,3,4-Tetrachlorobenzene as a sole source of carbon and energy, thereby releasing stoichiometric amounts of chloride (Potrawfke et al., 1998).

The following is a text-format Tetrachlorobenzene pathway map. An organism which can initiate the pathway is given, but other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in graphic (13k) format.

 
                        1,2,3,4-Tetrachlorobenzene 
                       Pseudomonas chlororaphis RW71
                                    |
                                    |
                                    | chlorobenzene
                                    | dioxygenase
                                    |
                                    v
                      cis-Chlorobenzene dihydrodiol
                                    |
                                    |
                                    | cis-chlorobenzene	 
                                    | dehydrodiol dehydrogenase
                                    |
                                    v
                           Tetrachlorocatechol
                                    |
                                    |
                                    | catechol
                                    | 1,2-dioxygenase
                                    |
                                    v
                     Tetrachloro-cis,cis-muconic acid
                                    |
                                    |
                                    | chloromuconate
                                    | cycloisomerase
                                    |
                                    v
                       2,3,5-Trichlorodienelactone
                                    |
                                    |
                                    | dienelactone
                                    | hydrolase
                                    |
                                    v
                     2,3,5-Trichloromaleylacetic acid
                                    |
                                    |
                                    | maleylacetate
                                    | reductase
                                    |
                                    v
                        2,4-Dichloro-3-oxoadipate
                                    |
                                    |
                                    v A
                                    |
                                    |
                                    v
                             Carbon dioxide
                                    |
                                    |
                                    |
                                    |
                                    |
                                    v
                           C1 Metabolic Cycle

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Page Author(s): Yan Zhang and Prasad Kotharu

April 20, 2012 Contact Us

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