The EAWAG-BBD Ibuprofen Pathway

• cis-1,2-Diol-2-hydroibuprofen-CoA -----> Propanoyl-CoA + Isobutylcatechol (reacID# r1736)
• 5-Formyl-2-hydroxy-7-methyl-octa-2,4-dienoate -----> 2-Hydroxy-5-isobutylhexa-2,4-dienoate (reacID# r1738)
• Ibuprofen -----> Ibuprofen-CoA (reacID# r1734)
• Ibuprofen-CoA -----> cis-1,2-Diol-2-hydroibuprofen-CoA (reacID# r1735)
• Isobutylcatechol -----> 5-Formyl-2-hydroxy-7-methyl-octa-2,4-dienoate (reacID# r1737)

• cis-1,2-Diol-2-hydroibuprofen-CoA (compID# c1500)
• 5-Formyl-2-hydroxy-7-methyl-octa-2,4-dienoate (compID# c1502)
• 2-Hydroxy-5-isobutylhexa-2,4-dienoate (compID# c1503)
• Ibuprofen [15687-27-1] (compID# c1498)
• Ibuprofen-CoA (compID# c1499)
• Isobutylcatechol (compID# c1501)
• Propanoyl-CoA [317-66-8] (compID# c0363)

• EC 1.2.1.- 5-Formyl-2-hydroxy-7-methyl-octa-2,4-dienoate dehydrogenase (enzymeID# e1168)
• EC 1.13.11.- ibuprofen-CoA dioxygenase (enzymeID# e1165)
• EC 1.13.11.- isobutylcatechol 2,3-dioxygenase (enzymeID# e1167)
• EC 2.3.1.- cis-1,2-diol-2-hydroibuprofen-CoA thiolase (enzymeID# e1166)
• EC 6.2.1.- ibuprofen--CoA ligase (enzymeID# e1164)

Page Author(s): Andrea Hopper, Lynda Ellis and Shawn Balcome
Fri Jun 24 16:35:35 CDT 2011 Contact Us

This is the EAWAG-BBD compounds and reactions page for the Ibuprofen Pathway.
It was generated on May 31, 2025 at 10:48:22 AM CDT.

© 2025, EAWAG.