From 5-Oxo-4,5-dihydropyrrole-2-carboxylate to 2-Oxoglutarate

Graphic of the reaction.

Reference

Hormann, K., & Andreesen, J. A. (1991). A flavin-dependent oxygenase reaction initiates the degradation of pyrrole-2-carboxylate in Arthrobacter strain Py1 (DSM 6386). Archives of Microbiology, 157, 43-48.

Search Medline for pyrrole-2-carboxylate metabolism AND bacteria.

21 citations on March 09, 2012.

                      5-Oxo-4,5-dihydropyrrole-2-carboxylate                       
                                         |
                                         |  H2O
  5-oxo-4,5-dihydropyrrole-2-carboxylate | /
                                 amidase |/
                                 3.5.2.- |
                                         |
                                  ExPASy |
                                         |
                                         v
                          [2-Amino-4-carboxybut-2-enate]                           
                                         |
                                         |  H2O
                                         | /
                                         |/
                                         |
                                         |\
                                         | \
                                         |  NH3
                                         v
                                  2-Oxoglutarate                                   

EAWAG-BBD Biotransformation rules in accord with this reaction:

secondary Amide -----> Carboxylate + primary Amine (bt0067)

primary Imine -----> Aldehyde (bt0391)

Page Author(s): Melissa Straffon
October 08, 2005 Contact Us

This is the EAWAG-BBD reaction, reacID# r0984.
It was generated on November 16, 2025 at 3:52:19 PM CST.

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