1,2,3-Tribromopropane Degradation Pathway

1,2,3-Tribromopropane Pathway Map

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This pathway was contributed by Danijela Markovic, University of Minnesota, BioC/MicE 5309.

1,2,3-Tribromopropane (TBP) is toxic organic compounds that has been released into environment via agricultural usage or the improper disposal of industrial waste (Bosma et al., 1999). 1,2,3-Tribromopropane is potent in causing organ damage (kidney and testis) in rats. Extensive necrosis is evident at 85 mumol/kg in kidney and at 170 mumol/kg in testis (Lag et al., 1994). Also 1,2,3-tribromopropane causes DNA damages. It has been shown that 1,2,3-tribromopropane is mutagenic in strains TA1535 and TA100 of Salmonella typhurinum (Lag et al., 1991). Also 1,2,3-tribromopropane induces dominant lethal mutation in the early spermatide stage of SD male rats (Saito-Suzuki et al., 1982).

The recombinant strain Agrobacterium radiobacter strain AD1(pTB3) has the ability to utilize 1,2,3-tribromopropane as a sole carbon source. The initial step in the degradation of 1,2,3-tribromopropane is dehalohenation to 2,3-dibromo-1-propanol (Bosma et al., 1999).

The following is a text-format 1,2,3-tribromopropane pathway map. An organisms which can initiate the pathway is given, but other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in graphic (12kb) format.

                                  1,2,3-Tribromopropane
                           Agrobacterium radiobacter strain AD1(pTB3)
                                            |
                                            |
                                            | haloalkane
                                            | dehalogenase
                                            |
                                            v
                                2,3-Dibromo-1-propanol
                                            |
                                            |
                                            | halohydrin hydrogen-
                                            | halide-lyase A
                                            |
                                            v
	                      (RS)-3-Bromo-1,2-epoxypropane
                                            |
                                            |
                                            | epoxide
                                            | hydrolase A
                                            |
                                            v
                               (RS)-3-Bromo-1,2-propanediol
                                            |
                                            |
                                            | halohydrin hydrogen-
                                            | halide-lyase A
                                            |
                                            v
                              (RS)-3-Hydroxy-1,2-epoxypropane
                                            |
                                            |
                                            | epoxide
                                            | hydrolase A
                                            |
                                            v
                                         Glycerol
                                            |
                                            |
                                            |
                                            |
                                            |
                                            v
                                       Intermediary
                                        Metabolism
                                           KEGG

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Page Author(s): Danijela Markovic

April 17, 2013 Contact Us

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