Rule bt0352
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2-Oxopent-4-enoate derivative -> Pyruvate derivative + Acetaldehyde or Ketone
1-Methyl-2-oxo derivative -> Acetate + RH
| Aerobic Likelihood: | | Likely |
EAWAG-BBD Reaction(s):
Acetylpyruvate -----> Pyruvate + Acetate (reacID# r0095)
4-iso-Propylcatechol -----> Pyruvate + 3-Methyl-2-butanone (reacID# r1728)
Comments:
This rule is a continuation of the extradiol (meta) ring cleavage pathway and handles all 2-oxopent-4-enoate derivatives produced by bt0351. It includes hydration of the C4-C5 double bond (bt0021) to form a 4-hydroxy-2-oxopentanoate derivative and subsequent aldolytic cleavage (bt0043) of the C3-C4 bond to yield, in the case where C4 is unsubstituted, pyruvate and acetate derivatives. If C4 does contain a functional group, pyruvate and ketone derivatives will be formed. 5-Chloro-2-oxopent-4-enoate follows this pathway and produces pyruvate and chloroacetate, which undergoes hydrolytic dehalogenation (bt0022) to yield glycolate. This rule also handles intermediates, such as appropriate compounds with -OH on C4.
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Page Author(s):
Michael Turnbull
July 15, 2010
This is the EAWAG-BBD biotransformation rule, ruleID# bt0352.
It was generated on November 23, 2024 2:24:16 AM CST.
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