Rule bt0352

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Pattern 2744        All patterns
2-Oxopent-4-enoate derivative -> Pyruvate derivative + Acetaldehyde or Ketone
1-Methyl-2-oxo derivative -> Acetate + RH

Aerobic Likelihood:              Likely

EAWAG-BBD Reaction(s):
Acetylpyruvate -----> Pyruvate + Acetate (reacID# r0095)
4-iso-Propylcatechol -----> Pyruvate + 3-Methyl-2-butanone (reacID# r1728)

This rule is a continuation of the extradiol (meta) ring cleavage pathway and handles all 2-oxopent-4-enoate derivatives produced by bt0351. It includes hydration of the C4-C5 double bond (bt0021) to form a 4-hydroxy-2-oxopentanoate derivative and subsequent aldolytic cleavage (bt0043) of the C3-C4 bond to yield, in the case where C4 is unsubstituted, pyruvate and acetate derivatives. If C4 does contain a functional group, pyruvate and ketone derivatives will be formed. 5-Chloro-2-oxopent-4-enoate follows this pathway and produces pyruvate and chloroacetate, which undergoes hydrolytic dehalogenation (bt0022) to yield glycolate. This rule also handles intermediates, such as appropriate compounds with -OH on C4.

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Page Author(s): Michael Turnbull
July 15, 2010

This is the EAWAG-BBD biotransformation rule, ruleID# bt0352.
It was generated on September 19, 2017 6:37:40 AM CDT.

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