From 6-Hydroxypseudooxynicotine to 6-Hydroxy-3-succinoylpyridine

Graphic of the reaction.

Medline reference
Gherna RL, Richardson SH, Rittenberg SC. J Biol Chem (1965) 240(9): 3669-74.

Search Medline for 6-hydroxypseudooxynicotine OR 6-hydroxy-3-succinoylpyridine.
4 citations on March 09, 2012.
                6-Hydroxypseudooxynicotine                 
                             |
                             |  H2O
  6-hydroxypseudooxynicotine | /
               dehydrogenase |/
                     1.5.-.- |
                             |\
                      ExPASy | \
                             |  2H+ + 2e- + NH2CH3
                             v
          [6-hydroxy-4-oxo-4-(3-pyridinebutanal)]          
                             |
                             |  OH-
                             | /
                             |/
                             |
                             |\
                             | \
                             |  2e- + 2H+
                             v
               6-Hydroxy-3-succinoylpyridine               
Display a pathway starting from this reaction.

EAWAG-BBD Biotransformation rules in accord with this reaction:
secondary Amine -----> Amine + Aldehyde or Ketone (bt0063)
Aldehyde -----> Carboxylate (bt0003)

[Nicotine] [BBD Main Menu]

Page Author(s): Michael Turnbull
December 27, 2007 Contact Us

This is the EAWAG-BBD reaction, reacID# r1441.
It was generated on September 22, 2017 7:19:01 PM CDT.

© 2017, EAWAG.