3-Phenylpropionate Pathway Map

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This pathway was contributed by Thanh Trinh, University of Minnesota.

3-Phenylpropionate is widely available in the natural environment. It is produced from putrefaction of proteins in soil or breakdown of several constituents of plants, such as lignin, various oils and resins. In industry, 3-Phenylpropioate is produced from a mild hydrogenation of 3-Phenylpropenoate. The degradation of 3-phenylpropionate by microbes is important not only in the natural environment, but also in wine making, aging, and storage industries.

This pathway is based on Diaz et al., 1998.

The following is a text-format 3-Phenylpropionate pathway map. Organisms which can initiate the pathway are given, but the other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in graphic (10K) format.

             3-Phenylpropionate                  
             Escherichia coli
                   K-12 
                     |
                     |
                     | 3-phenylpropionate
                     | dioxygenase
                     |
                     v
        cis-3-(3-Carboxyethyl)-3,5-
          cyclohexadiene-1,2-diol      
                     |
                     |
                     | 3-phenylpropionate-
                     | dihydrodiol dehydrogenase
                     |
                     v            
      3-(2,3-Dihydroxyphenyl)propionate
                     |
                     |
                     | 3-(2,3-dihydroxyphenyl)
                     | propionate-1,2-dioxygenase
                     |
                     v
          2-Hydroxy-6-keto-nona-
             2,4-dienedioate
                     |
                     |
                     | 2-hydroxy-6-ketonona-
                     | 2,4-dienedioate hydrolase
                     |
                     v
     2-Hydroxypenta- + Succinate
     2,4-dieneoate         |
            |              |
            |              |
            |              |
            |              |
            |              |
            v              v
   to the Toluene    Intermediary
          pathway   Metabolism (KEGG)

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Page Author(s): Thanh Trinh

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