Mandelate Degradation Pathway

Mandelate Pathway Map

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This pathway was contributed by Huawei Chen, and completed by Dong Jun Oh, University of Minnesota.

Mandelate racemase (MR) from Pseudomonas putida ATCC 12633 catalyzes the equilibration of the (R)-mandelate and (S)-mandelate (Schafer et al., 1996). In the mandelate pathway, (S)-mandelate dehydrogenase is specific for the (S) enantiomer, thus requiring the racemase to allow (R)-mandelate oxidation to benzoate.

The following is a text-format mandelate pathway map. An organism which can initiate the pathway is given, but other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in graphic (5k) format.

                  (R)-Mandelate
            Pseudomonas putida ATCC 12633
                        |
                        |
                        | mandelate racemase
                        |
                        | 
                        v                               
                  (S)-Mandelate
                        |
                        |
                        | L-mandelate dehydrogenase
                        |
                        |
                        v                     from the
                  Benzoylformate <---------- Metamitron
                        |                     Pathway
                        |
                        | benzoylformate decarboxylase
                        |
                        |
                        v
                   Benzaldehyde
                        |
                        |
                        |
                        |
                        v
                      to the
                  Toluene Pathway

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Page Author(s): Huawei Chen and Dong Jun Oh

July 11, 2017 Contact Us

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