3,3'-Dithiodipropionic Acid (DTDP) is a precursor to microbially synthesized polythioesters (PTEs). Tetrathiobacter mimigardefordensis strain DPN7(T) is able to use DTDP as the sole carbon source for growth. DTDP is first reduced to 3-mercaptopropionate (3-MP). 3-MP is one of the most frequently detected thiols in natural aquatic environments, and is also synthesized chemically for use as a bisphenol A cocatalyst. 3-MP is dioxygenated to 3-sulfinopropionate (3SP). After CoA ligation, the sulfino group is cleaved to form propionyl-CoA (Wübbeler et al., 2008).
The following is a text-format 3,3'-Dithiodipropionate pathway map. An organism which can initiate the pathway is given, but other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in graphic (8k) format.
3,3'-Dithiodipropionate Tetrathiobacter mimigardefordensis strain DPN7(T) | | | 3,3'-dithiodipropionate | disulfide reductase | v 3-Mercaptopropionate | | | 3-mercaptopropionate | dioxygenase | v 3-Sulfinopropionate | | | succinyl-CoA | synthetase | v 3-Sulfinopropionate-CoA | | | 3-sulfinopropionate-CoA | desulfinase | v Propionyl-CoA | | | v Intermediary Metabolism (KEGG)
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