Dimethyl isophthalate Pathway Map

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This pathway was contributed by Jason Vevea, University of Minnesota, BioC/MicE 5309 and completed by Luke Kane, University of Minnesota.

Dimethyl isophthalate (DMI) is a white flaked solid, soluble in most organic solvents and belongs to a category of compounds called dimethyl phthalate esters (DMPE). DMI is used to modify the structural integrity of plastics such as polyethylene terephthalate (PET). Health concerns may be warranted due to the estrogenic mimicking properties of DMI (Cheung et al., 2007).

The complementary metabolism of Klebsiella oxytoca Sc and Methylobacterium mesophilicum Sr can degrade DMI to non toxic metabolites (Li et al., 2007). Variovorax paradoxus T4 and Xanthobacter sp. (Cheung et al., 2007), and Rhodococcus erythropolis 5D and R. ruber 1B (Aleshchenkova et al., Microbiol. 66: 515-518, 1997) can also degrade DMI by the same pathway. Other phthalate degradation pathways are found on the Phthalate Family Map.

The following is a text-format Dimethyl isophthalate pathway map. Organisms which can initiate the pathway are given, but other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in graphic (8k) format.

            Dimethyl isophthalate       
   	    Klebsiella oxytoca Sc
               Xanthobacter sp.     
            Rhodococcus ruber 1B
           Variovorax paradoxus T4
         Rhodococcus erythropolis 5D
                     |
                     |
                     | dimethyl isophthalate
                     | esterase
                     | 
                     v                               
           Monomethyl isophthalate 
       Methylobacterium mesophilicum Sr    
                     |
                     |
                     | monomethyl isophthalate
                     | esterase
                     | 
                     v 
                Isophthalate
                     |
                     |
                     | isophthalate 3,4-  
                     | dioxygenase
                     |
                     v
      4-Hydro-3,4-dihydroxyisophthalate
                     |
                     | 4-hydro-3,4-
                     | dihydroxyisophthalate  
                     | dehydrogenase 
                     |
                     v
	   3,4-Dihydroxybenzoate
                     |
                     |   
                     |
                     v
		   to the
                  Vanillin
                  Pathway     

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Page Author(s): Jason Vevea and Luke Kane

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