Cyclopropanecarboxylate Pathway Map

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This pathway was contributed by Sean Anderson and completed by Yogesh Kale, University of Minnesota.

Cyclopropanecarboxylate, like other compounds containing cyclopropane ring, is a highly strained aliphatic compound. Cyclopropane rings can be found both in nature (e.g. in pyrethrins and hypoglycins), as well as in some synthetic compounds such as miticides, herbicides, and drugs (Toraya, 2004).

The bacterium Rhodococcus rhodochrous can use cyclopropanecarboxylate as its sole source of carbon and energy. Cyclopropanecarboxylate is converted to 3-Hydroxybutyryl-CoA via cyclopropanecarboxyl-CoA. 3-Hydroxybutyryl-CoA is further consumed by the process of oxidative degradation. The cyclopropanecarboxylate ring opening reaction is still being researched and the enzyme for it is yet to be characterized. However Toraya et al., (2004) have shown that the enzyme acting on cyclopropanecarboxyl-CoA is inducible. Formation of an intermediate crotonyl-CoA is also proposed but no evidence is provided.

The following is a text-format Cyclopropanecarboxylate pathway map. An organism which can initiate the pathway is given, but other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in graphic (6k) format.


        Cyclopropanecarboxylate
        Rhodococcus rhodochrous
                  |
                  | cyclopropanecarboxy
                  | late-CoA ligase
                  | 
                  v 
       Cyclopropanecarboxyl-CoA
                  |
                  | cyclopropanecarboxyl-
                  | CoA decyclase
                  |
                  v 
           [Crotonoyl-CoA]
                  |
                  | enoyl-CoA
                  | hydratase 
                  |
                  v 
      (3S)-3-Hydroxybutyryl-CoA
                  |
                  |
                  |
                  v
                to the
               Benzoate
             (anaerobic)
               Pathway



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Page Author: Sean Anderson, Yogesh Kale

July 11, 2017 Contact Us

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