s-Triazine Metabolism Metapathway Map

This metapathway map was contributed by Doug Hershberger of the University of Minnesota.

The s-triazine compounds include many pesticides of widespread use in agriculture. S-triazines are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms (pictured below).

This meta-pathway will primarily discuss the s-triazine pesticides and similar compounds; however, there are many other groups of s-triazine compounds.

In the s-triazine family, atrazine is the most widely used, and the most studied. The pathways below are largely derived from knowledge of the atrazine degradation pathways. Other s-triazines may be degraded by similar mechanisms.

In representing the compounds below, we show only the primary ring, amino residues and R-groups. The composition of the R-groups for each compound is designated by the abbreviations employed by Cook (1987, FEMS Microbiol. Rev. 46 93-116) or developed here, as summarized below.

The points at which many common triazines feed into the catabolism pathway are shown below. The degree to which these compounds have been studied is indicated by the appearance of the arrow from the compound name to its entry to the pathway.

	Well Known: Degradation of this compound is well established. Most of the steps and many of the genes catalyzing them have been identified.
	Known: Degradation of this compound is well established. Many of the steps and a few of the genes catalyzing them have been identified.
	Partially Known: Degradation of this compound has been observed. Intermediates have been identified which suggest the steps shown here.
	Putative: Degradation of this compound has been observed. Based on its degradation and the few intermediates identified, it may be degraded through the shown pathway.
	Unknown: Partial degradation of this compound has been observed. It possibly may be degraded through the shown pathway.

Click on a boxed name or phrase for more information. Click on a to see an example of that type of reaction in the atrazine pathway.

Page Author(s): Doug Hershberger and Michael Turnbull

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