Rule bt0082
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2-Ketocarboxylate -> Carboxylate + CO2
Aerobic Likelihood: |   | Neutral |
EAWAG-BBD Reaction(s):
4-Hydroxy-3-nitrophenylpyruvate -----> 4-Hydroxy-3-nitrophenylacetate (reacID# r1599)
4-Hydroxyphenylpyruvate -----> Homogentisate (reacID# r0298)
4-Hydroxyphenylpyruvate -----> 4-Hydroxyphenylacetate (reacID# r0299)
2-Oxobutanoate -----> Propanoyl-CoA (reacID# r0358)
Comments:
After decarboxylation, some 2-ketocarboxylates transiently form an aldehyde, but this is quickly oxidized to the carboxylate. Others directly form the carboxylate, and the carboxylate is shown here. The rule does not decarboxylate 2-oxoacids that are cleaved to remove pyruvate or similar compounds rather than CO2, such as 2-oxo-3-ene, 2-oxo-4-imine, and 2,4-dioxo acids.
Similarities:
bt0051: 2- or 3- substituted Carboxylate --> RH + CO2
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Page Author(s):
Bo Kyeng Hou, Michael Turnbull and Jiun-guo Yu
June 02, 2009
This is the EAWAG-BBD biotransformation rule, ruleID# bt0082.
It was generated on December 2, 2024 4:51:22 AM CST.
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