From Diphenyl ether to Phenol and Catechol

Graphic of the reaction.

Medline reference
Schmidt S, Wittich RM, Erdmann D, Wilkes H, Francke W, Fortnagel P. Appl Environ Microbiol (1992) 58(9): 2744-50.

Search Medline titles for diphenyl ether AND phenol AND bacteria.
29 citations on September 13, 2012. 
           Diphenyl ether            
                  |
                  |  NADH + O2 + H+
   diphenyl ether | /
  1,2-dioxygenase |/
        1.14.12.- |
                  |\
           ExPASy | \
                  |  NAD+
                  v
[cis-1,2-dihydrodihydroxydiphenyl ether]
                  |
                  |
                  |
                  |
                  |
                  |
                  |
                  v
          Phenol + Catechol
Display a pathway starting from this reaction.

EAWAG-BBD Biotransformation rules in accord with this reaction:
polynuclear Aromatic system -----> 1,2-dioxygenation and cleavage at connecting atom (bt0374)
[Phenol Family ] [BBD Main Menu]

Page Author(s): Lynda Ellis and Michael Turnbull
March 15, 2008 Contact Us

This is the EAWAG-BBD reaction, reacID# r1453.
It was generated on April 15, 2026 at 8:25:05 PM CDT. 

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