From 3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione to (3E,1Z)-4,5-9,10-Diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate

Graphic of the reaction.

Medline reference

Horinouchi M, Kurita T, Yamamoto T, Hatori E, Hayashi T, Kudo T. Biochem Biophys Res Commun (2004) 324(2): 597-604.

Search Medline for meta-cleavage enzyme AND testosterone.

7 citations on March 09, 2012.

           3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione           
                                        |
                                        |  O2
                               3,4-DHSA | /
                        4,5-dioxygenase |/
                             1.13.11.25 |
                                  Kyoto |\
                                 ExPASy | \
                                        |  H+
                                        v
  (3E,1Z)-4,5-9,10-Diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate   

EAWAG-BBD Biotransformation rules in accord with this reaction:

vic-Dihydroxybenzenoid -----> extradiol ring cleavage (bt0008)

Page Author(s): Andrew Rabins
April 22, 2006 Contact Us

This is the EAWAG-BBD reaction, reacID# r1151.
It was generated on November 14, 2025 at 2:57:54 AM CST.

© 2025, EAWAG.