From Benzo(a)pyrene to Benzo(a)pyrene-cis-11,12-dihydrodiol

Graphic of the reaction.

Medline reference
Moody JD, Freeman JP, Fu PP, Cerniglia CE. Appl Environ Microbiol (2004) 70(1): 340-5.

Search Medline titles for benzo(a)pyrene AND bacteria.
9 citations on August 31, 2012. 
             Benzo(a)pyrene              
                    |
                    |  O2 + NADH + H+
     benzo(a)pyrene | /
  11,12-dioxygenase |/
          1.14.12.- |
                    |\
             ExPASy | \
                    |  NAD+
                    v
  Benzo(a)pyrene-cis-11,12-dihydrodiol
Display a pathway starting from this reaction.

EAWAG-BBD Biotransformation rules in accord with this reaction:
vic-unsubstituted Aromatic -----> vic-Dihydrodihydroxyaromatic (bt0367)
[Benzo[a]pyrene] [BBD Main Menu]

Page Author(s): Edward Zhang
February 12, 2006 Contact Us

This is the EAWAG-BBD reaction, reacID# r1124.
It was generated on December 4, 2025 at 6:23:39 PM CST. 

© 2025, EAWAG.