From 4,5-Dihydroxypyrene to Phenanthrene-4,5-dicarboxylate

Graphic of the reaction.

Medline reference
Vila J, Lopez Z, Sabate J, Minguillon C, Solanas AM, Grifoll M. Appl Environ Microbiol (2001) 67(12): 5497-505.

Search Medline for pyrene [TITLE] AND phenanthrene AND bacteria.
66 citations on March 09, 2012. 
             4,5-Dihydroxypyrene             
                      |
                      |  O2
  4,5-dihydroxypyrene | /
          dioxygenase |/
            1.13.11.- |
                      |\
               ExPASy | \
                      |  2H+
                      v
       Phenanthrene-4,5-dicarboxylate
Display a pathway starting from this reaction.

EAWAG-BBD Biotransformation rules in accord with this reaction:
vic-Dihydroxyaromatic -----> intradiol ring cleavage (bt0254)
[Pyrene] [BBD Main Menu]

Page Author(s): Nathaniel Keith
August 14, 2005 Contact Us

This is the EAWAG-BBD reaction, reacID# r0936.
It was generated on November 12, 2025 at 6:02:15 PM CST. 

© 2025, EAWAG.