From Dibenzo-p-dioxin to 2,2',3-Trihydroxydiphenylether

Graphic of the reaction.

Medline reference
Wittich RM, Wilkes H, Sinnwell V, Francke W, Fortnagel P. Appl Environ Microbiol (1992) 58(3): 1005-10.

Search Medline for dibenzo-p-dioxin AND dioxygenase.
33 citations on March 09, 2012. 
           Dibenzo-p-dioxin            
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                   |  O2 + NADH + H+
      dibenzofuran | /
  4,4a-dioxygenase |/
         1.14.12.- | Search GenBank, 3 hits on Apr. 03, 2012
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            ExPASy | \
                   |  NAD+
                   v
[4,4a-dihydroxy-dihydro-dibenzo-p-dioxin]
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                   v
    2,2',3-Trihydroxydiphenylether
Display a pathway starting from this reaction.

EAWAG-BBD Biotransformation rules in accord with this reaction:
polynuclear Aromatic system -----> 1,2-dioxygenation and cleavage at connecting atom (bt0374)
[Dibenzo-p-dioxin] [BBD Main Menu]

Page Author(s): Greg S. Bill
August 14, 2005 Contact Us

This is the EAWAG-BBD reaction, reacID# r0571.
It was generated on February 17, 2026 2:17:23 PM CST. 

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