From 2-Hydroxy-5-methyl-cis,cis-muconic semialdehyde to Formate and 2-Oxohex-trans-4-enoate

Graphic of the reaction.

Medline reference
Diaz E, Timmis KN. J Biol Chem (1995) 270(11): 6403-411.

Search Medline for 2-hydroxymuconate semialdehyde hydrolase.
20 citations on June 21, 2012. 
          2-Hydroxy-5-methyl-cis,cis-muconic semialdehyde          
                                 |
                                 |  H2O
  2-hydroxymuconate semialdehyde | /
                       hydrolase |/
                         3.7.1.9 | Search GenBank, 101 hits on Apr. 03, 2012
                           Kyoto |
                          ExPASy |
                                 |
                                 v
                 Formate + 2-Oxohex-trans-4-enoate
Display a pathway starting from this reaction.

EAWAG-BBD Biotransformation rules in accord with this reaction:
1-Aldo/keto-2,4-diene-5-ol -----> Carboxylate + 1-ene-4-one (bt0040)
[p-Xylene] [BBD Main Menu]

Page Author(s): Stephen Stephens
August 14, 2005 Contact Us

This is the EAWAG-BBD reaction, reacID# r0181.
It was generated on February 6, 2026 7:08:54 PM CST. 

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