From p-Toluate to 4-Methylcyclohexa-3,5-diene-1,2-cis-diol-1-carboxylic acid

Graphic of the reaction.

Medline reference
Walsh TA, Ballou DP, Mayer R, Que L Jr. J Biol Chem (1983) 258(23): 14422-7.

Search Medline titles for benzoate 1,2-dioxygenase.
11 citations on June 21, 2012. 
                           p-Toluate                           
                               |
                               |  NADH + O2 + H+
                      benzoate | /
               1,2-dioxygenase |/
                    1.14.12.10 | Search GenBank, 17 hits on Apr. 03, 2012
                         Kyoto |\
                        ExPASy | \
                               |  NAD+
                               v
  4-Methylcyclohexa-3,5-diene-1,2-cis-diol-1-carboxylic acid
Display a pathway starting from this reaction.

EAWAG-BBD Biotransformation rules in accord with this reaction:
1-carboxy-2-unsubstituted Aromatic -----> 1-Carboxy-1,2-dihydroxy-2-hydroaromatic (bt0368)
[p-Xylene] [BBD Main Menu]

Page Author(s): Mili Jeon and Stephen Stephens
August 14, 2005 Contact Us

This is the EAWAG-BBD reaction, reacID# r0178.
It was generated on February 17, 2026 3:33:02 PM CST. 

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