From 2-Chloro-cis,cis-muconate to trans-4-Carboxymethylenebut-2-en-4-olide

Graphic of the reaction.
Medline reference: Hammer A, Hildenbrand T, Hoier H, Ngai KL, Schlomann M, Stezowski JJ. J Mol Biol (1993) 232(1): 305-7.
Search Medline for chloromuconate cycloisomerase.: 36 citations on March 09, 2012.

          2-Chloro-cis,cis-muconate          
                      |
                      |
       chloromuconate |
       cycloisomerase |
              5.5.1.7 | Search GenBank, 227 hits on Apr. 03, 2012
                Kyoto |\
               ExPASy | \
                      |  Cl^-
                      v
  trans-4-Carboxymethylenebut-2-en-4-olide

Display a pathway starting from this reaction.

EAWAG-BBD Biotransformation rules in accord with this reaction:: 2-Halo-cis,cis-muconate -----> trans-Dienelactone derivative (bt0181)

[Chlorobenzene] [BBD Main Menu]

Page Author(s): Ryan McLeish
August 14, 2005 Contact Us

This is the EAWAG-BBD reaction, reacID# r0111.
It was generated on January 20, 2026 at 12:03:18 AM CST.

© 2026, EAWAG.