From 2-Hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate to Salicylate and 2-Oxopent-4-enoate

Graphic of the reaction.

Medline reference
Bunz PV, Falchetto R, Cook AM. Biodegradation (1993) 4(3): 171-8.

Search Medline for 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase.
25 citations on March 09, 2012. 
                  2-Hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate                  
                                            |
                                            |  H2O
  2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate | /
                                  hydrolase |/
                                    3.7.1.8 | Search GenBank, 213 hits on Apr. 03, 2012
                                      Kyoto |\
                                     ExPASy | \
                                            |  H+
                                            v
                             Salicylate + 2-Oxopent-4-enoate
Display a pathway starting from this reaction.

EAWAG-BBD Biotransformation rules in accord with this reaction:
1-Aldo/keto-2,4-diene-5-ol -----> Carboxylate + 1-ene-4-one (bt0040)
[Dibenzofuran] [BBD Main Menu]

Page Author(s): Anthony Ouellette and Ryan McLeish
December 16, 2005 Contact Us

This is the EAWAG-BBD reaction, reacID# r0028.
It was generated on February 8, 2025 at 6:09:31 AM CST. 

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