From Benzo(a)pyrene to Benzo(a)pyrene-cis-4,5-dihydrodiol

Graphic of the reaction.

Medline reference
Moody JD, Freeman JP, Fu PP, Cerniglia CE. Appl Environ Microbiol (2004) 70(1): 340-5.

Search Medline titles for Benzo(a)pyrene AND bacteria.
9 citations on September 04, 2012. 
            Benzo(a)pyrene             
                   |
                   |  O2 + NADH + H+
    benzo(a)pyrene | /
   4,5-dioxygenase |/
         1.14.12.- |
                   |\
            ExPASy | \
                   |  NAD+
                   v
  Benzo(a)pyrene-cis-4,5-dihydrodiol
Display a pathway starting from this reaction.

EAWAG-BBD Biotransformation rules in accord with this reaction:
vic-unsubstituted Aromatic -----> vic-Dihydrodihydroxyaromatic (bt0367)
[Benzo[a]pyrene] [BBD Main Menu]

Page Author(s): Edward Zhang
February 12, 2006 Contact Us

This is the EAWAG-BBD reaction, reacID# r1126.
It was generated on November 8, 2025 at 10:05:11 AM CST. 

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