From 3-Methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon to 2,5,6-Trihydroxy-3-methylpyridine and 2-Oxobut-3-enanoate

Graphic of the reaction.

Medline reference
Schach S, Schwarz G, Fetzner S, Lingens F. Biol Chem Hoppe Seyler (1993) 374(3): 175-81.

Search Medline for 3-methylquinoline degradation.
3 citations on March 09, 2012. 
                                 3-Methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon                                 
                                                              |
                                                              |  H2O
  3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon | /
                                            hydratase-adolase |/
                                                      4.2.1.- |
                                                              |
                                                       ExPASy |
                                                              |
                                                              v
                                   2,5,6-Trihydroxy-3-methylpyridine + 2-Oxobut-3-enanoate
Display a pathway starting from this reaction.

EAWAG-BBD Biotransformation rules in accord with this reaction:
3-Methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon derivative -----> 2,5,6-Trihydroxy-3-methylpyridine derivative (bt0282)
[3-Methylquinoline] [BBD Main Menu]

Page Author(s): Sandy Etienne and David J De Grio
February 01, 2006 Contact Us

This is the EAWAG-BBD reaction, reacID# r0051.
It was generated on February 18, 2026 3:11:29 PM CST. 

© 2026, EAWAG.