From Hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid to Hydrogen (1R,2R)-1,2-dihydroxypropylphosphonic acid

Graphic of the reaction.

Medline reference

Fillgrove KL, Pakhomova S, Newcomer ME, Armstrong RN. J Am Chem Soc (2003) 125(51): 15730-1.

Search Medline for fosfomycin resistance AND epoxide hydrolase.

2 citations on August 29, 2012.

  Hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid   
                            |
                            |  H2O
                    epoxide | /
                  hydrolase |/
                   3.3.2.10 | Search GenBank, 79 hits on Apr. 03, 2012
                      Kyoto |
                     ExPASy |
                            |
                            v
  Hydrogen (1R,2R)-1,2-dihydroxypropylphosphonic acid   

EAWAG-BBD Biotransformation rules in accord with this reaction:

Epoxide -----> Glycol (bt0050)

Page Author(s): David Joseph De Grio
November 13, 2005 Contact Us

This is the EAWAG-BBD reaction, reacID# r1064.
It was generated on December 2, 2024 at 11:15:43 AM CST.

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