4-Hydroxyacetophenone Pathway Map

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This pathway was contributed by Wenjun Kang, University of Minnesota.

One of the aerobic strategies used by microorganisms to degrade ketones is to perform the Baeyer-Villiger oxidation to form an ester, which can then be readily hydrolyzed. The metabolism of cyclic and aliphatic ketones, for example, the biodegradation of cyclohexanone (Donoghue et al., 1975) and 2-tridecanone (Britton et al., 1977), has been reported. In addition, the degradation of aryl ketones, such as 4-hydroxyacetophenone (Tanner et al., 2000), can also proceed by formation of an ester by the action of a Baeyer-Villiger type of monooxygenase.

The following is a text-format 4-Hydroxyacetophenone pathway map. An organism which can initiate the pathway is given, but other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in graphic (5k) format.

                  4-Hydroxyacetophenone <------ from the Bisphenol A Pathway
                  Pseudomonas putida JD1
                Pseudomonas fluorescens ACB
                           |
                           |
                           | 4-hydroxyacetophenone
                           | monooxygenase
                           |
                           v
                 4-Hydroxyphenyl Acetate
                           |
                           |
                           | arylesterase
                           |                          
                           v
                      Hydroquinone
                           |
                           |
                           |
                           |
                           v
                         to the
                  4-Nitrophenol Pathway

[Compounds and Reactions] [BBD Main Menu]

Page Author(s): Wenjun Kang

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