Rule bt0082

[Pathway Prediction Engine] [All Rules List] [BBD Main Menu]

Pattern 2982
2-Ketocarboxylate -> Carboxylate + CO2

Aerobic Likelihood:              Neutral

EAWAG-BBD Reaction(s):
4-Hydroxy-3-nitrophenylpyruvate -----> 4-Hydroxy-3-nitrophenylacetate (reacID# r1599)
4-Hydroxyphenylpyruvate -----> Homogentisate (reacID# r0298)
4-Hydroxyphenylpyruvate -----> 4-Hydroxyphenylacetate (reacID# r0299)
2-Oxobutanoate -----> Propanoyl-CoA (reacID# r0358)

After decarboxylation, some 2-ketocarboxylates transiently form an aldehyde, but this is quickly oxidized to the carboxylate. Others directly form the carboxylate, and the carboxylate is shown here. The rule does not decarboxylate 2-oxoacids that are cleaved to remove pyruvate or similar compounds rather than CO2, such as 2-oxo-3-ene, 2-oxo-4-imine, and 2,4-dioxo acids.

bt0051: 2- or 3- substituted Carboxylate --> RH + CO2

Contact Us if you have any comments on rule bt0082.
[Pathway Prediction Engine] [All Rules List] [BBD Main Menu]

Page Author(s): Bo Kyeng Hou, Michael Turnbull and Jiun-guo Yu
June 02, 2009

This is the EAWAG-BBD biotransformation rule, ruleID# bt0082.
It was generated on September 20, 2017 8:29:24 PM CDT.

© 2017, EAWAG.