Rule bt0021

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Pattern 3858        All patterns
1-Oxo 2- or 3-ene derivative -> 1-Oxo-3-hydroxy derivative


Aerobic Likelihood:              Neutral

EAWAG-BBD Reaction(s):
5-Chloro-2-oxopent-4-enoate -----> 5-Chloro-4-hydroxy-2-oxopentanate (reacID# r1436)
cis-3-Chloroacrylic acid -----> Malonate semialdehyde (reacID# r0688)
trans-3-Chloroacrylic acid -----> Malonate semialdehyde (reacID# r0689)
Cyclohex-1,5-diene-1-carboxyl-CoA -----> 6-Hydroxycyclohex-1-ene-1-carboxyl-CoA (reacID# r0203)
Cyclohex-1-ene-1-carboxyl-CoA -----> 2-Hydroxycyclohexane-1-carboxyl-CoA (reacID# r0191)
3,4-Dehydroadipyl-CoA -----> Succinyl-CoA + Acetyl-CoA (reacID# r1750)
6-Hydroxycyclohex-1-ene-1-carboxyl-CoA -----> 2,6-Dihydroxycyclohexane-1-carboxyl-CoA (reacID# r0204)
(2E,4E)-2-Hydroxyhexa-2,4-dienoate -----> 4-Hydroxy-2-oxohexanoate (reacID# r1281)
cis-2-Hydroxypenta-2,4-dienoate -----> 4-Hydroxy-2-oxovalerate (reacID# r0101)
Isohexenyl-glutaconyl-CoA -----> 3-Hydroxy-3-isohexeneylglutaryl-CoA (reacID# r1167)
(5R)-Menth-2-enone -----> (5R)-3-Hydroxymenthone (reacID# r1184)
cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA -----> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA (reacID# r0990)
trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA -----> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA (reacID# r0992)
Naphthyl-2-methylene-succinyl-CoA -----> Naphthyl-2-hydroxymethyl-succinyl-CoA (reacID# r1259)
cis-2-Oxohept-3-ene-1,7-dioate -----> 2,4-Dihydroxy-hept-trans-2-ene-1,7-dioate (reacID# r0369)
2-Oxohex-trans-4-enoate -----> 4-Hydroxy-2-oxohexanoate (reacID# r0182)
Perillyl-CoA -----> 2-Hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA (reacID# r1002)
E-Phenylitaconyl-CoA -----> (Hydroxymethylphenyl)succinyl-CoA (reacID# r0331)
3-(4-Sulfophenyl)butyrate enoyl-CoA -----> 3-Hydroxy-3-(4-sulfophenyl)butyryl-CoA (reacID# r1665)

Comments:
This rule handles the hydration of activated double bonds alpha or beta to the oxo group found in thioesters, carboxylates and ketones.

Similarities:
bt0335: trans-D2-Enoyl-CoA --> 3-Hydroxyacyl-CoA

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Page Author(s): Bo Kyeng Hou, Dave Roe, Michael Turnbull and Jiun-guo Yu
April 13, 2008

This is the EAWAG-BBD biotransformation rule, ruleID# bt0021.
It was generated on September 25, 2017 4:33:55 AM CDT.

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