From 7-Chloro-5-phenyl-3H-1,4-benzodiazepin-2-one to 2-Amino-N-(2-benzoyl-4-chlorophenyl)acetamide

Graphic of the reaction.

Medline reference
Ambrus G, Albrecht K, Horvath G. Acta Microbiol Acad Sci Hung (1975) 22(2): 145-52.

Search Medline for fungal diazepam metabolism.
11 citations on March 15, 2013.
                         7-Chloro-5-phenyl-3H-1,4-benzodiazepin-2-one                          
                                               |
                                               |  H2O
  7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-one | /
                                cyclohydrolase |/
                                       3.5.-.- |
                                               |
                                        ExPASy |
                                               |
                                               v
                         2-Amino-N-(2-benzoyl-4-chlorophenyl)acetamide                         
Display a pathway starting from this reaction.

EAWAG-BBD Biotransformation rules in accord with this reaction:
cyclic Imine -----> Ketone + Amine (bt0391)

[Diazepam] [BBD Main Menu]

Page Author(s): Lynda Ellis and Michael Turnbull
September 06, 2011 Contact Us

This is the EAWAG-BBD reaction, reacID# r1761.
It was generated on November 21, 2017 5:19:46 PM CST.

© 2017, EAWAG.